Gavin Whitlock: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

Don't use scam websites

1

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition

Paul V. Fish, Christopher Deur, Xinmin Gan, Keri Greene, David Hoople, Malcolm Mackenny, Kimberly S. Para, Keith Reeves, Thomas Ryckmans, Cory Stiff, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

2

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

Alex, Alexander, Millan, David S., Perez, Manuel, Wakenhut, Florian, Whitlock, Gavin A.

Journal:

Year:

2011

Language:

english

File:

PDF, 310 KB

english, 2011

3

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Jones, Peter, Storer, R. Ian, Sabnis, Yogesh A., Wakenhut, Florian M., Whitlock, Gavin A., England, Katherine S., Mukaiyama, Takasuke, Dehnhardt, Christoph M., Coe, Jotham W., Kortum, Steve W., Chrenc

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.98 MB

english, 2017

4

Enantioselective Synthesis of ent-Stellettamide A: Asymmetric Dipolar Cycloadditions with Me3SiCHN2

Gavin A. Whitlock, Erick M. Carreira

Journal:

Helvetica Chimica Acta

Year:

2000

Language:

english

File:

PDF, 205 KB

english, 2000

5

Stereoselective Synthesis of Tetrahydropyran-3-ones by Rearrangement of Oxonium Ylides Generated from Metal Carbenoids.

J. Stephen Clark, Gavin Whitlock, Shende Jiang, Ngozi Onyia

Journal:

Year:

2004

File:

PDF, 107 KB

2004

6

ChemInform Abstract: Potent and Selective α1A Adrenoceptor Partial Agonists — Novel Imidazole Frameworks.

Gavin A. Whitlock, Paul E. Brennan, Lee R. Roberts, Alan Stobie

Journal:

Year:

2009

File:

PDF, 18 KB

2009

7

ChemInform Abstract: Discovery of Novel Azepine Series of Potent and Selective 5-HT2C Agonists as Potential Treatments for Urinary Incontinence.

Paul E. Brennan, Gavin A. Whitlock, Danny K. H. Ho, Kelly Conlon, Gordon McMurray

Journal:

Year:

2010

File:

PDF, 13 KB

2010

8

A novel series of highly selective inhibitors of MMP-3

Gavin A. Whitlock, Kevin N. Dack, Roger P. Dickinson, Mark L. Lewis

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 264 KB

english, 2007

9

Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity

Paul V. Fish, Nancy S. Barta, David L.F. Gray, Thomas Ryckmans, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 242 KB

english, 2008

10

6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective α1A adrenoceptor partial agonists

Lee R. Roberts, Paul V. Fish, R. Ian Storer, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.31 MB

english, 2009

11

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration

Florian Wakenhut, Gill A. Allan, Paul V. Fish, M. Jonathan Fray, Anthony C. Harrison, Rachel McCoy, Stephen C. Phillips, Alan Stobie, Dominique Westbrook, Simon L. Westbrook, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 276 KB

english, 2009

12

Catalytic asymmetric hydroboration with heterotopic P-N ligands: Trends in enantioselectivity with increased steric demand

Jean Marc Valk, Gavin A. Whitlock, Timothy P. Layzell, John M. Brown

Journal:

Tetrahedron: Asymmetry

Year:

1995

Language:

english

File:

PDF, 210 KB

english, 1995

13

N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors

Paul V. Fish, M. Jonathan Fray, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 132 KB

english, 2007

14

1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity

Gavin A. Whitlock, Julian Blagg, Paul V. Fish

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 199 KB

english, 2008

15

Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

Gavin A. Whitlock, Kelly Conlon, Gordon McMurray, Lee R. Roberts, Alan Stobie, Richard J. Thurlow

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 135 KB

english, 2008

16

Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity

Gavin A. Whitlock, Paul V. Fish, M. Jonathan Fray, Alan Stobie, Florian Wakenhut

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 249 KB

english, 2008

17

N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors

Florian Wakenhut, Paul V. Fish, M. Jonathan Fray, Ian Gurrell, James E. Mills, Alan Stobie, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 229 KB

english, 2008

18

Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists

Lee R. Roberts, Justin Bryans, Kelly Conlon, Gordon McMurray, Alan Stobie, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 193 KB

english, 2008

19

Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity

Chitalu C. Musonda, Gavin A. Whitlock, Michael J. Witty, Reto Brun, Marcel Kaiser

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 147 KB

english, 2009

20

Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity

Chitalu C. Musonda, Gavin A. Whitlock, Michael J. Witty, Reto Brun, Marcel Kaiser

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 313 KB

english, 2009

21

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: Design, synthesis and structure–activity relationships

Paul V. Fish, Mark D. Andrews, M. Jonathan Fray, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 627 KB

english, 2009

22

Potent and selective α1A adrenoceptor partial agonists—Novel imidazole frameworks

Gavin A. Whitlock, Paul E. Brennan, Lee R. Roberts, Alan Stobie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 370 KB

english, 2009

23

Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence

Paul E. Brennan, Gavin A. Whitlock, Danny K.H. Ho, Kelly Conlon, Gordon McMurray

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 512 KB

english, 2009

24

A concise enantioselective synthesis of the fungal metabolite (+)-decarestrictine L

J. Stephen Clark, Thomas C. Fessard, Gavin A. Whitlock

Journal:

Year:

2006

Language:

english

File:

PDF, 171 KB

english, 2006

25

A short synthesis of (±)-decarestrictine L

J.Stephen Clark, Gavin A. Whitlock

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 153 KB

english, 1994

26

Asymmetric Synthesis of Cyclic Ethers by Rearrangement of Oxonium Ylides Generated from Chiral Copper Carbenoids

J.Stephen Clark, Mark Fretwell, Gavin A. Whitlock, Christopher J. Burns, David N.A. Fox

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 639 KB

english, 1998

27

Structure–activity relationships of N-substituted piperazine amine reuptake inhibitors

M. Jonathan Fray, Gerwyn Bish, Paul V. Fish, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 126 KB

english, 2006

28

N-(1,2-Diphenylethyl)piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor

M. Jonathan Fray, Gerwyn Bish, Alan D. Brown, Paul V. Fish, Alan Stobie, Florian Wakenhut, Gavin A. Whitlock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 105 KB

english, 2006

29

Understanding CYP2D6 interactions

Marcel J. de Groot, Florian Wakenhut, Gavin Whitlock, Ruth Hyland

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 1.09 MB

english, 2009

30

Cardiovascular profiles of beta3 agonists

Joanne L. Leaney, Sonia Roberts, Jolie Harris, Michelle Hemkens, Julie Selkirk, Neil Attkins, Piet Van Der Graaf, Oladipupo Adeyemi, Mark Dewhurst, Kerry af Forselles, Gavin Whitlock

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 53 KB

english, 2010

31

Identification of Type-II Inhibitors Using Kinase Structures

Frank Lovering, Joseph McDonald, Gavin A. Whitlock, Paul A. Glossop, Chris Phillips, Andrew Bent, Yogesh Sabnis, Mark Ryan, Lori Fitz, Julie Lee, Jeanne S. Chang, Seungil Han, Ravi Kurumbail, Atli Tho

Journal:

Chemical Biology & Drug Design

Year:

2012

Language:

english

File:

PDF, 572 KB

english, 2012

32

A systematic review of phenotypic responses to between-population outbreeding

Raj Whitlock, Gavin B Stewart, Simon J Goodman, Stuart B Piertney…

Journal:

Environmental Evidence

Year:

2013

Language:

english

File:

PDF, 401 KB

english, 2013

33

Enantioselective Synthesis of ent -Stellettamide A via a Novel Dipolar Cycloaddition Reaction of (Trimethylsilyl)diazomethane

Whitlock, Gavin A., Carreira, Erick M.

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 143 KB

english, 1997

34

Stereoselective synthesis of tetrahydropyran-3-ones by rearrangement of oxonium ylides generated from metal carbenoids

Stephen Clark, J., Whitlock, Gavin, Jiang, Shende, Onyia, Ngozi

Journal:

Chemical Communications

Year:

2003

Language:

english

File:

PDF, 105 KB

english, 2003

35

Small-molecule anti-inflammatory drug compositions for the treatment of asthma: a patent review (2013 – 2014)

Glossop, Paul, Whitlock, Gavin, Gibson, Karl

Journal:

Expert Opinion on Therapeutic Patents

Year:

2015

Language:

english

File:

PDF, 641 KB

english, 2015

36

Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity

Mowbray, Charles E., Braillard, Stéphanie, Speed, William, Glossop, Paul A., Whitlock, Gavin A., Gibson, Karl R., Mills, James E. J., Brown, Alan D., Gardner, J. Mark F., Cao, Yafeng, Hua, Wen, Morgan

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 478 KB

english, 2015

37

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells

Ward, Jennifer A., McLellan, Lauren, Stockley, Martin, Gibson, Karl R, Whitlock, Gavin A., Knights, Charlotte, Harrigan, Jeanine A., Jacq, Xavier, Tate, Edward W.

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.12 MB

english, 2016

38

Inhibition of the Liver Insulin Responsive Transcription Factor Forkhead Box Protein O1 Fails to Rescue Stress Hyperglycemia in Trauma and Hemorrhage

Garcia Whitlock, Anna E., Gavin, Matthew, Sims, Carrie A., Titchenell, Paul M.

Journal:

Journal of the American College of Surgeons

Year:

2019

File:

PDF, 249 KB

2019